Neonatal Handling on Amphetamine-Induced Sensitization

Neonatal Handling on Amphetamine-Induced Sensitization

Neonatal Handling on Amphetamine-Induced Sensitization

Last updated on October 3rd, 2023 at 03:09 pm

For this Effects of Neonatal Handling on Amphetamine-Induced Sensitization in Male and Female Adolescent Rats: Implications for Attention Deficit Hyperactivity Disorder (ADHD), you need to write 2 detailed paragraph on each article.

Paper should answer most of the following research question:

  • Research sleep and ADHD
  • What is sleep-induced? What is the role of norepinephrine, dopamine, serotonin, and sleep? – Normally, you need to suppress these systems in order to fall asleep and have a good quality of sleep.
  • Norepinephrine (noradrenaline)- Epinephrine (adrenaline) – is tied to the sympathetic nervous system (fight or flight), stress (norepinephrine and epinephrine)
  • Amphetamine increases norepinephrine and dopamine
  • Ritalin (methylphenidate) increases norepinephrine and dopamine
  • What are the recommended hours of sleep – 15-16 hours (14 hours) – be familiar with what is the recommended amount of sleep.
  • Less than recommended sleep, results in norepinephrine, dopamine, and serotine more active than usual, and if this occurs during 0-3 years of age, it leads to a disruption of these systems – and long-term may be responsible for the symptoms you see in ADHD kids.
  • Does handling disrupt sleep? What are the various handling procedures?
  • What is the normal sleep patterns of neonatal rats
  • What is the normal sleep patterns of the dam (mom)
  • What age period in neonatal rats is equivalent to the first 2-3 years of life.
  • What dose of AMPH produces sensitization in adolescent rats.
  • For how long should the sessions be (the pretreatment phase and challenge phase) – 60 min? 90 min? 120 min?
  • What behaviors change with AMPH administration o Locomotor (the main one we can measure) o Rearing, stereotypy (sniffing, grooming), etc. – We can’t measure automatically.



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